Examining the evidence on the causal effect of HAART on transmission of HIV using the Bradford Hill criteria. In recent years, evidence has accumulated regarding the ability of HAART to prevent HIV transmission. Early supportive evidence was derived from observational, ecological and population-based studies. More recently, a
randomized clinical trial showed that immediate use of HAART led to a 96%
decrease in HIV transmission events within HIV serodiscordant heterosexual
couples. However, the generalizability of the effect of HAART, and the population-level impact on HIV transmission continues to generate substantial debate. We, therefore, conducted a review of the evidence regarding the preventive effect of HAART on HIV transmission within the context of the Bradford Hill criteria for causality.
randomized clinical trial showed that immediate use of HAART led to a 96%
decrease in HIV transmission events within HIV serodiscordant heterosexual
couples. However, the generalizability of the effect of HAART, and the population-level impact on HIV transmission continues to generate substantial debate. We, therefore, conducted a review of the evidence regarding the preventive effect of HAART on HIV transmission within the context of the Bradford Hill criteria for causality.
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