Factor VIII%, and plasminogen activator inhibitor-1 (PAI-1) antigen and lower total Protein S% (TPS) but have not been examined in HCV. We assessed the independent association of HCV with these 4 measures of hemostasis in a multicenter, prospective study of HIV: the Women's Interagency HIV Study. We randomly selected 450 HCV-infected (anti-HCV+ with detectable plasma HCV
RNA) and 450 HCV-uninfected (anti-HCV-) women. HCV was the main exposure of interest in regression models.