Treatment of Kaposi sarcoma in children with HIV-1 infection. Kaposi sarcoma (KS) remains the second most frequently diagnosed HIV-related malignancy (HRM) worldwide and most common HRM in sub-Saharan Africa where HIV is most prevalent and human herpesvirus 8 (HHV-8), the precipitating agent for the development of KS, is endemic. The majority of KS patients would likely benefit from systemic chemotherapy in addition to the initiation of antiretroviral therapy (ART). However, as paediatric staging and treatment criteria are not readily available, there are no uniform treatment criteria. To describe the efficacy and effectiveness of current treatment options for HIV-associated KS in ART-treated paediatric populations. We used standard Cochrane methods to search electronic databases and conference proceedings with relevant search terms without limits to language.
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