Evaluation of two line probe assays for rapid detection of Mycobacterium tuberculosis, tuberculosis drug resistance, and non-tuberculosis mycobacteria in HIV-infected TB suspects. Line probe assays(LPA), nucleic acid tests used for the rapid diagnosis of tuberculosis(MTB), non-tuberculosis mycobacteria(NTM) and MTB drug resistance, have limited performance data in HIV-infected individuals, in whom paucibacillary tuberculosis(TB) is common. In this study, the strategy of testing sputum with GenoType MTBDRplus(MTBDR-Plus) and GenoType Direct(Direct) was compared to a gold standard of 1 mycobacterial growth indicator(MGIT) liquid culture. HIV+ TB suspects from Southern Africa and South America with <7 days of TB treatment had 1 sputum tested with Direct LPA, MTBDR-Plus LPA, smear microscopy, MGIT, biochemical mycobacterial speciation, and culture-based drug susceptibility testing (DST).
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