Gut Epithelial Barrier Dysfunction and Innate Immune Activation Predict Mortality in Treated HIV Infection. While inflammation predicts mortality in treated HIV infection, the prognostic significance of gut barrier dysfunction and phenotypic T cell markers remains unclear. We assessed immunologic predictors of mortality in a case-control study within the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) using conditional logistic regression. Cases (n=64) dying within 12 months of treatment-mediated viral suppression were matched to two controls (n=128) by duration of ART-mediated viral suppression, nadir CD4+ T cell count, age, gender, and prior cytomegalovirus (CMV) retinitis. A similar secondary analysis was conducted in the less advanced SCOPE cohort.
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