Antiretroviral therapy: stubborn limitations persist. The development in the mid-1990s of combination antiretroviral treatment (ART) for the management of HIV infections is one of medicine's greatest success stories. For individuals who can access and adhere to treatment at early stages of the infection, the risk of developing an AIDS-defining complication is vanishingly small. Treatment, however, does not fully restore health. Treated adults have a higher than expected risk of developing many non-AIDS complications, including cardiovascular disease ...
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