Soluble markers of inflammation and coagulation, but not T-cell activation, are predictors of non-AIDS-defining morbid events during suppressive antiretroviral treatment. Defining the association of non-AIDS-defining events with inflammation and immune activation among HIV-infected persons who are virologically suppressed on antiretroviral therapy (ART) is critical to identifying interventions to decrease their occurrence. We conducted a case-control study of HIV-infected subjects virologically suppressed after 1 year of ART. Cases had a myocardial infarction, stroke, non-AIDS-defining cancer, serious bacterial infection or death. Controls were matched for age, sex, pre-ART CD4+T-cells and regimen. PBMC and plasma from the pre-ART, after 1 year of ART and pre-event time-points were analyzed for activated CD4+/CD8+T-cells, plasma interleukin-6 (IL-6), soluble tumor necrosis factor receptors (sTNFR)-I and -II, soluble CD14, kynurenine:tryptophan (K/T) ratio and D-dimer. Conditional logistic regression analysis was used to study the association between biomarkers and outcomes with adjustment for potential confounders.
GlobalResearch at UCSF presents the broad scope of health research that is being conducted by UCSF researchers worldwide