Changes in the timing of antiretroviral therapy initiation in HIV-infected patients with tuberculosis in Uganda: a study of the diffusion of evidence into practice in the global response to HIV/AIDS. We aimed to determine the extent to which emerging evidence and changing guidelines regarding timing of antiretroviral therapy (ART) among HIV-infected patients with tuberculosis (TB) influenced "real world" clinical practice in Uganda. Methods. We evaluated ART-naïve, HIV-infected adults starting TB therapy at two HIV clinics in Uganda between August 26, 2006 and September 29, 2012. We used multivariate regression to calculate associations between four calendar periods reflecting publication of seminal clinical studies or changes in guidelines and timing of ART after TB therapy initiation.
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