Artemisinin-based Combination Therapies are Efficacious and Safe for Treatment of Uncomplicated Malaria in HIV-infected Ugandan Children. Artemisinin-based combination therapies (ACTs) are highly efficacious and safe but data from HIV-infected children concurrently receiving antiretroviral therapy (ART) and ACTs are limited. We evaluated 28-day outcomes following malaria treatment with artemether-lumefantrine (AL) or dihydroartemisinin-piperaquine (DP) in two cohorts of HIV-infected Ugandan children taking various ART regimens. In one cohort, children under six years of age were randomized to lopinavir/ritonavir (LPV/r) or non-nucleoside reverse transcriptase inhibitors (NNRTI) based ART and treated with AL for uncomplicated malaria. In another cohort, children under 12 months of age were started on nevirapine-based ART if they were eligible, and randomized to AL or DP for the treatment of their first and all subsequent uncomplicated malaria episodes.
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